Immune Response
Immune Response to HIV
Dendritic Cell Therapeutic Vaccine Helps Immune Cells Control HIV Replication
- Details
- Category: HIV Vaccines
- Published on Tuesday, 15 January 2013 00:00
- Written by Liz Highleyman
A therapeutic vaccine made from dendritic cells primed with heat-inactivated HIV stimulated immune cells to mount a response against the virus without it infecting and killing them, according to a study described in the January 2, 2013, issue of Science Translational Medicine.
Immune Activation Raised HIV Risk in CAPRISA Trial, but Some Develop Protective Antibodies
- Details
- Category: HIV Prevention
- Published on Tuesday, 06 November 2012 00:00
- Written by Liz Highleyman
Women in the CAPRISA 004 vaginal gel trial who showed evidence of prior immune activation had an increased likelihood of becoming infected with HIV, researchers recently reported. Another CAPRISA analysis found that 2 women exhibitedbroadly cross-neutralizing antibodies targeting a newly emergent antigen on HIV's envelope -- a discovery that could advance vaccine research.
Immediate Antiretroviral Therapy Reduces HIV Infection of Resting CD4 T-Cells
- Details
- Category: HIV Basic Science
- Published on Tuesday, 12 June 2012 00:00
- Written by Liz Highleyman
Starting antiretroviral therapy (ART) during the acute phase of HIV infection appears to reduce the number of latently infected resting CD4 T-cells in most people, but this may not be the case for individuals with very few initially infected cells, according to a study published in the May 29, 2012, advance online edition of Proceedings of the National Academy of Sciences.
Researchers Shed Light on Natural Control of HIV
- Details
- Category: HIV Basic Science
- Published on Friday, 15 June 2012 00:00
- Written by Press Release
Certain T-cell antigen receptor types are associated with greater response to HIV, which may help explain how a small proportion of people are able to naturally control HIV without antiretroviral therapy, according to a report in the June 10, 2012, advance online edition of Nature Immunology.
More Gut Th17 Cells Linked to Better Control of HIV-like Virus in Monkeys
- Details
- Category: HIV Basic Science
- Published on Friday, 08 June 2012 00:00
- Written by Press Release
Rhesus macaque monkeys that had a larger number of a specific type of helper T-cells -- known as TH17 cells -- in their blood and intestinal tissue at the time of infection with SIV (a monkey virus related to HIV) had lower viral load set-points, according to a study published in the May 30, 2012, issue of Science Translational Medicine.
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