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Experimental HIV Vaccine to Enter Large Clinical Trial in South Africa

An investigational vaccine that showed promise in an earlier study will advance to a large-scale efficacy trial at 15 sites in South Africa, the U.S. National Institutes of Health (NIH) announced on May 18, marking HIV Vaccine Awareness Day. The new trial, HVTN 702, designed to determine if the vaccine is safe, well-tolerated, and effective at preventing HIV infection, is due to start this November, with results expected in 4 years.

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Model Suggests HIV Vaccine Could Play Key Role in Ending AIDS

Even a modestly effective HIV vaccine would likely be cost-effective and could make a major contribution to a sustainable response to the global HIV/AIDS epidemic, especially in combination with the scale-up of other interventions including prompt antiretroviral therapy (ART) and pre-exposure prophylaxis (PrEP), according to a report in the January 5 edition of PLoS ONE.

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Vaccine Combo Demonstrates Protection Against HIV-like Virus in Monkey Study

Administering a 2-part prime-boost vaccine prevented infection in half of a dozen rhesus monkeys repeatedly exposed to simian immunodeficiency virus (SIV), and antibody responses against viral envelope proteins appeared to be the key to protection, according to a study published in the July 2 advance edition of Science magazine.

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Studies Advance Understanding of Broadly Neutralizing Antibodies Against HIV

Three recent studies funded by the National Institutes of Health have shed further light on broadly neutralizing antibodies that may play a role in developing an effective HIV vaccine. The studies demonstrated techniques for stimulating immune cells to produce antibodies that either could stop HIV from infecting human cells in the laboratory, or had the potential to evolve into such antibodies, according to a National Institute of Allergy and Infectious Diseases press release.

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May 18 is HIV Vaccine Awareness Day

May 18 is HIV Vaccine Awareness Day, an annual opportunity to call attention to progress in vaccine science and the need for further research on both preventive vaccines that stop new HIV infections and therapeutic vaccines that help the immune system fight existing infection.

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