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Combination HIV Vaccine Efficacy Trial Launches in South Africa

A new HIV vaccine efficacy study -- the first in 7 years -- got underway this week in Cape Town, South Africa. The HVTN 702 trial will evaluate the safety and effectiveness of 2 experimental vaccines -- ALVAC-HIV and a gp120 protein subunit vaccine -- related to a combination that previously demonstrated modest efficacy in the RV144 trial in Thailand. The study aims to enroll more than 5400 sexually active adults and results are expected in late 2020.

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HIVR4P 2016: Huge Diversity in HIV Vaccine Research Discussed at Prevention Conference

The HIV vaccine research field is currently going through probably its most fertile and diverse period yet. A high proportion of presentations at the second HIV Research for Prevention conference (HIVR4P 2016) in Chicago last week were devoted to a multiplicity of different approaches scientists are taking towards making an effective vaccine.

[Produced in collaboration with aidsmap.com]

At the opening plenary, Georgia Tomaras of Duke University gave an overview of the field. It has been a long journey towards developing vaccines with even partial efficacy: the first trial of any kind was in 1987 and the first large efficacy trial -- which failed -- was in 2003. But the RV144 vaccine -- which in 2009 showed limited efficacy, reducing HIV infections among recipients by 31% (and 60% a year after its first dose) -- injected new energy into the field, not least because its effect seemed due to an unexpected kind of anti-HIV response.

At the International AIDS Conference (AIDS 2016) held in Durban in July researchers reported that a pilot study, HVTN100, of an RV144-type vaccine adapted to the strain predominant in South Africa it produced a stronger response than the original RV144 vaccine. This meant it had passed the criteria for being advanced to a large efficacy trial, HVTN 702. This will start next month -- the first HIV vaccine efficacy trial for 7 years, since HVTN 505 started in July 2009.

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AIDS 2016: New HIV Vaccine Efficacy Trial Set to Start this Year

A new efficacy trial for an HIV vaccine -- only the seventh ever conducted in the history of the epidemic -- will start this November, delegates heard at the 21st International AIDS Conference (AIDS 2016) taking place this week in Durban. The HVTN 702 study will enroll 5400 men and women in southern Africa, and is planned to last for 4 years. In May it was announced that a pilot study, HVTN 100, had met the criteria for the vaccine being taken forward into the larger study. But this week was the first time researchers revealed how well it had met those criteria.

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Coverage of HIV Research for Prevention Conference (HIVR4P 2016)

HIVandHepatitis.com coverage of the 2016 HIV Research for Prevention Conference (HIVR4P 2016), October 17-21, in Chicago.

Conference highlights include current and experimental pre-exposure prophylaxis (PrEP), microbicide rings and other options, and investigational HIV vaccines.

Full listing of coverage by topic

HIVR4P 2016 website

10/22/16

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Experimental HIV Vaccine to Enter Large Clinical Trial in South Africa

An investigational vaccine that showed promise in an earlier study will advance to a large-scale efficacy trial at 15 sites in South Africa, the U.S. National Institutes of Health (NIH) announced on May 18, marking HIV Vaccine Awareness Day. The new trial, HVTN 702, designed to determine if the vaccine is safe, well-tolerated, and effective at preventing HIV infection, is due to start this November, with results expected in 4 years.

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