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CROI 2015: Triple-Drug Combination Superior for Preventing Mother-to-Child HIV Transmission

Implementing the World Health Organization (WHO) recommendation of 3-drug antiretroviral treatment during pregnancy leads to a significantly lower rate of mother-to-child HIV transmission, a 7-country randomized study has shown. The results of the PROMISE study, conducted in sub-Saharan Africa and India, were presented at the 2015 Conference on Retroviruses and Opportunistic Infections (CROI) last week in Seattle.

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CROI 2015: 3-Drug ART Prevents Vertical HIV Transmission [VIDEO]

Pregnant women treated with a standard 3-drug antiretroviral therapy (ART) regimen were less likely to transmit HIV to their babies that those given only zidovudine (AZT; Retrovir) and nevirapine (Viramune), according to results from the PROMISE study presented at the 2015 Conference on Retroviruses and Opportunistic Infections (CROI) last week in Seattle.

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[Mary Glenn Fowler, CROI, February 24, 2015]

"We had very low transmission rates les than 2% for both strategies, however there was significantly decreased transmission for the triple arms compared to the zidovudine arm," Mary Glenn Fowler from Johns Hopkins School of Medicine said at a CROI press conference. But the triple regimen was associated with an overall increase in moderate but not severe maternal adverse events, as well as a higher risk of moderate adverse pregnancy outcomes such as low birth weight and pre-term delivery.

SEE ALSO: CROI 2015: Triple-Drug Combination Superior for Preventing Mother-to-Child HIV Transmission

3/5/15

Reference

MG Fowler, M Qin, SA Fiscus, et al. PROMISE: Efficacy and Safety of 2 Strategies to Prevent Perinatal HIV Transmission
. 2015 Conference on Retroviruses and Opportunistic Infections. Seattle, February 23-24, 2015. Abstract 31LB.

7. AIDS Long-Term Survivors and Aging with HIV

Long-term survivors of the AIDS epidemic continued to make news in 2014, with the first-ever National HIV/AIDS Long-Term Survivors Awareness Day. There was more confirmation that people who start HIV treatment early may have a life expectancy matching that of uninfected individuals, but older people with HIV face health issues including cardiovascular disease and frailty.

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Saturday is National Black HIV/AIDS Awareness Day

Saturday, February 7, is National Black HIV/AIDS Awareness Day (NBHAAD), an opportunity to raise awareness about the disproportionate burden of HIV/AIDS among African Americans. According to the Centers for Disease Control and Prevention (CDC), African Americans represent approximately 12% of the U.S. population, but accounted for 44% of new HIV infections and 43% of all people living with HIV in 2010.

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PLoS Publishes Free Special Collection on HIV Care and Prevention for Sex Workers

PLoS, publisher of open-access research, has announced a special collection of articles on the health of female sex workers, focusing on delivery and scale-up of HIV care and prevention interventions. UNAIDS and other organizations have recognized sex workers as of the key affected populations in the HIV/AIDS epidemic.

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