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Neurocognitive Problems

CROI 2014: Neurocognitive Problems, Depression, and Early ART in People with HIV

In a particularly challenging area of HIV care where research is complicated by gaps in knowledge and invasive clinical procedures, there was significant attention to neurological manifestations -- or neuroAIDS -- at this year’s Conference on Antiretroviral Agents and Chemotherapy (CROI 2014) last month in Boston.

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EACS 2013: Suicide Rates and Psychiatric Drug Use Among People with HIV

A study presented at the recent 14th European AIDS Conference found that the suicide rate among people with HIV in British Columbia had fallen 35-fold since 1996 and was now close to that of the general population. However, a second study from Denmark found rates of psychiatric drug use, especially sleeping pills and tranquilizers, to be 2-3 times higher among people with HIV than in the general population, and saw a marked rise in the use of antipsychotic drugs 7 or 8 years after diagnosis.

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ICAAC 2013: Depression Linked to Detectable HIV in Cerebrospinal Fluid

People who experience episodes of major depressive disorder (MDD) are significantly more likely to have detectable HIV in their cerebral-spinal fluid (CSF), according to an analysis of the large CHARTER study presented as a late-breaker poster at the 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC 2013) last week in Denver.

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ICAAC 2013: Switching from Atripla to Complera Reduces Central Nervous System Side Effects

People who switched single-tablet regimens from Atripla (efavirenz/tenofovir/emtricitabine) to Complera (rilpivirine/tenofovir/emtricitabine) maintained viral load suppression and saw improvement in central nervous system (CNS) side effects such as abnormal dreams and depression, according to a late-breaking poster presented at the 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) this month in Denver. Other studies looked at the safety and efficacy of Complera among women and black patients.

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Neurocognitive Impairment Common Among Youth with HIV

Approximately two-thirds of HIV positive young adults showed evidence of HIV-associated neurocognitive disorders (HAND), including impaired memory and fine motor control, according to a report in the August 21, 2013, advance edition of the Journal of Adolescent Health.

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