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Neurocognitive Problems

Mild Neurological Impairment Is Common During Early HIV Infection

People with HIV infection often have neurological signs and symptoms very soon after becoming infected -- even before they develop antibodies that show up on a test -- but these are typically mild to moderate and resolve after starting effective antiretroviral therapy (ART), according to a study published in the June 10 advance online edition of Neurology. These findings provide further evidence for starting treatment as soon as possible after HIV diagnosis.

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CROI 2016: Antidepressant Improves HIV-Related Cognitive Impairment

The SSRI antidepressant paroxetine (Paxil) was associated with a modest improvement in cognitive function and reduced central nervous system inflammation among people with HIV-related neurocognitive disorder, but the antifungal drug fluconazole showed no apparent benefit even though it reduced oxidative stress, according to a study presented at the Conference on Retroviruses and Opportunistic Infections (CROI 2016) last month in Boston.

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IAS 2015: HIV+ People with Asymptomatic Cognitive Impairment More Likely to Develop Symptoms

People with HIV who showed evidence of asymptomatic neurocognitive impairment at study entry were nearly twice as likely to progress to symptomatic HIV-associated neurocognitive disorders than those with initially normal neuropsychological tests, according to research presented at the 8th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention last month in Vancouver.

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CROI 2016: HIV in the Brain -- New Tools and Treatment Options to Keep Your Mind Beautiful

In the future, HIV-related neurocognitive disorder (HAND) may become less common because of the earlier use of antiretroviral therapy (ART), but neurological disease -- caused by a number of different factors -- will remain an important issue as people with HIV live longer, according to several presentations in a symposium called "A beautiful Mind, Keeping It," held at the annual Conference on Retroviruses and Opportunistic Infections (CROI 2016) in Boston.

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HIV May Cause Cognitive Impairment by Disrupting Brain's Garbage Disposal

HIV's Tat protein interferes with autophagy, a process by which damaged or unneeded cell components are broken down and eliminated, according to research published in the February 4 Journal of Neuroscience. This disruption can lead to neuron damage, but the immunosuppressant drug rapamycin was able to reverse this process in a study of mice.

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