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HIV-Related Conditions

CROI 2014: Vitamin D and Rosuvastatin Improve Bone Loss in People with HIV

A combination of high-dose vitamin D and calcium may help reduce bone loss after starting antiretroviral therapy (ART), according to a presentation at the Conference on Retroviruses and Opportunistic Infections (CROI 2014) last month in Boston. A related study found that rosuvastatin increased hip bone mineral density in HIV positive people on ART, though insulin resistance worsened.

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CROI 2014: Neurocognitive Problems, Depression, and Early ART in People with HIV

In a particularly challenging area of HIV care where research is complicated by gaps in knowledge and invasive clinical procedures, there was significant attention to neurological manifestations -- or neuroAIDS -- at this year’s Conference on Antiretroviral Agents and Chemotherapy (CROI 2014) last month in Boston.

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CROI 2014: Tesamorelin Growth-Hormone Releaser Reduces Liver Fat in People with HIV

Tesamorelin, a synthetic form of growth-hormone-releasing hormone (GHRH), which the FDA has approved to reduce excess visceral abdominal fat in people living with HIV, also reduced associated liver fat in an HIV positive cohort chosen for abdominal adiposity, according to the results from a randomized, placebo-controlled trial presented at the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) this week in Boston.

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CROI 2014: Researchers Discuss HIV, Aging, and Frailty

People living with HIV are at greater risk of geriatric syndromes such as frailty and difficulty with daily activities than HIV negative people of the same age -- and this can have a significant effect upon their quality of life as they age, according to several studies presented at the 14th Conference on Retroviruses and Opportunistic Infections (CROI 2014) last month in Boston.

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CROI 2014: Retrovirus Conference Now Underway in Boston

The 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) kicked off in Boston this week with a program for young investigators, a press conference on new hepatitis C treatments, and opening lectures on HIV immune response and cross-species transmission and an update on the epidemic in West Africa.

HIVandHepatitis.com will be on site all week bringing you the latest news.alt

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Men with HIV Have Higher Risk of Heart Disease

HIV positive men have more extensive atherosclerosis, or build-up of plaque in their arteries, than HIV negative men after taking into account other cardiovascular risk factors, potentially raising the risk of heart attack, according to an analysis from the large MACS cohort published in the April 1 Annals of Internal Medicine.

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CROI 2014: The Role of Interferon in HIV Response [VIDEO]

Although interferon is on its way out as a standard of care for hepatitis C, researchers are learning more about its role in HIV, conference vice chair Julie Overbaugh said at a media briefing on the opening day of the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) this week in Boston.

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CROI 2014: Heart Attack Link to Abacavir Persists in D:A:D Study

The nucleoside reverse transcriptase inhibitor abacavir (Ziagen, also in Epzicom or Kivexa) continues to be associated with a near-doubling of the risk of heart attack, according to the latest update from the Data Collection on Adverse events of Anti-HIV Drugs (D:A:D) study, presented to the 21st Conference on Retroviruses and Opportunistic Infections (CROI) this month in Boston.

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CROI 2014: Retrovirus Conference Starts Monday in Boston

The 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) will take place next week, March 3-6, at the Hynes Convention Center in Boston. HIVandHepatitis.com will be on site all week to bring you the latest news coverage about HIV, hepatitis C, and related topics.

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CROI 2014: Newborns Exposed to Tenofovir Have Lower Bone Content [VIDEO]

Infants born to women who took tenofovir during pregnancy had significantly lower bone mineral content than babies who were not exposed, according to study findings reported at the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) this month in Boston.

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Adolescents Born with HIV May Have Higher Heart Disease Risk

Nearly half of adolescents with lifelong HIV infection were found to have evidence of coronary artery atherosclerosis, putting them at elevated risk for cardiovascular disease, according to a study published in the December 23, 2013, advance edition of Circulation.

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CROI 2014: People with HIV More Likely to Die of Many Common Cancers

People with HIV are more likely to die from many common cancers than the rest of the U.S. population, according to a large comparative study presented at the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) this month in Boston.

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Cancer Is a Growing Concern Among People with HIV

People with HIV continue to experience higher rates of both AIDS-defining and non-AIDS cancers in the era of effective antiretroviral therapy (ART), according to a report in the February 20, 2014, issue of AIDS. Increased longevity alone does not explain the rise in non-AIDS cancer rates, and further research is needed on the causes and best treatments for cancer in this population, the study authors concluded.

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CROI 2014: Heart Attack Risk May Be Falling for People with HIV -- But Not for Women

A number of studies at last week’s 21st Conference on Retroviruses and Opportunistic Infections in Boston examined whether people with HIV have an elevated risk of heart attack and other manifestations of cardiovascular disease  (CVD). They came to different conclusions about whether having HIV is in itself a cardiovascular risk factor.

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Low CD4 Count Raises Risk of Heart Attack, Bone Loss

HIV positive people whose CD4 T-cell count falls below 200 cells/mm3 are at greater risk for myocardial infarction, though the heart attack rate is not elevated for people with counts of 500 cells/mm3 or more, researchers recently reported. Another study found that people with low CD4 counts have a higher likelihood of bone loss after starting antiretroviral therapy (ART).

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Coverage of the 2014 Conference on Retroviruses and Opportunistic Infections

HIVandHepatitis.com coverage of the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014), March 3-6, 2014, in Boston.

Conference highlights include new treatments for hepatitis C, HIV experimental therapies and treatment strategies, HIV cure research, HIV-related conditions, treatment as prevention and PrEP, and HIV/HCV coinfection.

Full listing by topic

Selected presentations and slide webcasts 

3/9/14

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HIV Infection Linked to Structural Heart Disease

People with HIV who have detectable viral load are more likely to have structural heart problems such as left ventricular hypertrophy, diastolic dysfunction, or pulmonary hypertension, according to research presented at the recent EuroEcho-Imaging 2013 conference in Istanbul.

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Coverage of the 2014 Conference on Retroviruses and Opportunistic Infections

HIVandHepatitis.com coverage of the 21st Conference on Retroviruses and Opportunistic infections (CROI 2014), March 3-6, 2014, in Boston.

Conference highlights include new treatments for hepatitis C, HIV experimental therapies and treatment strategies, HIV cure research, HIV-related conditions, treatment as prevention and PrEP, and HIV/HCV coinfection.

Full HIVandHepatitis.com coverage by topic

Selected presentations and slide webcasts 

3/9/14

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HIV Medicine Association Guidelines Emphasize Primary Care Needs of People with HIV on ART

The HIV Medicine Association (HIVMA) of the Infectious Disease Society of America (IDSA) this week released new Primary Care Guidelines for the Management of Persons Infected with Human Immunodeficiency Virus, focusing on primary care and prevention for HIV positive people on effective antiretroviral therapy (ART). The new guidelines, published in the November 13, 2013, online edition of Clinical Infectious Diseases (in print January 2014) "reflect the fact that people with HIV are now living normal life spans," according to an HIVMA/IDSA press release.

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CROI 2014: Depression and HIV are Risk Factors for Heart Failure Among Veterans

Both HIV infection and depression are independent risk factors for incident heart failure, and living with both HIV and depression multiplies the risk, according to an analysis of data from the Veterans Aging Cohort Study presented at the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) this week in Boston.

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Updated Pediatric HIV Opportunistic Infection Guidelines Emphasize Antiretroviral Therapy

The U.S. National Institutes of Health, Centers for Disease Control and Prevention, and other medical associations have released an updated version of Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Exposed and HIV-Infected Children. The latest revision emphasizes the importance of timely antiretroviral therapy as a key to preventing and managing OIs in infants and children with HIV.

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