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CROI 2015: Inflammation and Gut Damage Persist in People with HIV Despite Early ART

Inflammatory changes and damage to the gut begin very soon after initial HIV infection, and may not return to normal even when people start antiretroviral therapy (ART) very early, researchers reported at the recent 2015 Conference on Retroviruses and Opportunistic Infections (CROI) in Seattle. Biomarkers of inflammation, coagulation and fibrosis increased early on, and while they generally decreased after starting ART, they did not fall to levels seen in HIV-negative people.

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Very Early HIV Treatment May Delay Disease Progression, Raise CD4 Count

Starting antiretroviral therapy (ART) within the first 6 months after infection may slow immune system decline and raise CD4 T-cell counts, but the benefits may not last after treatment is stopped, according to a pair of studies published in January 17, 2013, New England Journal of Medicine.

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5 Drugs No Better than 3 for Treatment of Primary HIV Infection

An intensive antiretroviral therapy (ART) regimen consisting of 5 drugs from 4 different classes did not lead to better outcomes after 1 year than a standard 3-drug regimen started during acute or early HIV infection, according to study data presented at the 18th Conference on Retroviruses and Opportunistic Infections (CROI 2011) last week in Boston.alt

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IAS 2011: HIV Treatment In Primary Infection: 48 Week Course Modestly Delays CD4 Drop

A 48-week course of antiretroviral treatment started within six months of becoming infected modestly delays the need for lifelong treatment, reported Sarah Fidler of Imperial College, London, at the 6th International AIDS Society Conference (IAS 2011) in Rome.alt

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