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CROI 2017: Better Depression Care Could Improve Outcomes for HIV Treatment Programs


Improved management of depression and other mental health problems has the potential to improve the outcomes of HIV treatment programs, Pamela Collins of the U.S. National Institute of Mental Health reported at the recent Conference on Retroviruses and Opportunistic Infections in Seattle. Mental health treatment should be integrated into HIV services in resource-limited settings, she said.

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Diabetes, cardiovascular disease, cancer, lung disease, and other non-communicable diseases have an increasing impact on the health and quality of life of people living with HIV. Health services in low- and middle-income countries have been slow to implement programs to prevent, screen for and treat these diseases, but a number of projects have shown that this work can be integrated with HIV care.

Collins noted that mental health disorders are now considered along with non-communicable diseases in the third Sustainable Development Goal. But she said that whereas other non-communicable diseases increasingly affect people as they get older, the greatest burden of mental health problems occurs in adolescence and young adulthood. Around three-quarters of mental health disorders have begun by the age of 24.

A global meta-analysis showed that 18% of people had experienced a mental health disorder in the previous year and 29% had done so in their lifetime (23% in low- and middle-income countries, 32% in high-income countries). However, few people receive the treatment they need, especially in resource-limited settings.

Mental health disorders commonly occur among people living with chronic health conditions including HIV. The evidence from a range of conditions, such as diabetes, asthma, and arthritis, is that having untreated depression as well as another health condition is associated with being less able to function and having poorer health status.

Depression is the most common mental health comorbidity experienced by people living with HIV. In sub-Saharan Africa, the average prevalence of depression among people with HIV is around 8% (similar to that seen in general population samples in the region), but can be much higher in some groups.

Depression is more commonly experienced by women, older people, those who are unemployed, people with low CD4 cell counts, and people with more physical symptoms. People who have experienced childhood trauma or negative life events, and those with less social support, are more likely to be depressed.

The relationship between mental health disorders and HIV works in both directions, Collins said. Mental disorders can be a risk factor or increase vulnerability to HIV infection. At the same time, people may experience depression or anxiety as they adjust to a diagnosis or live with a chronic illness. Moreover, neuropsychiatric effects of the virus can in some cases lead to cognitive changes or dementia.

Providing HIV medical care and antiretroviral treatment specifically is in itself associated with improvements in mental health, due to the improvements in physical health which it brings. Nonetheless, a number of cases of depression persist, requiring intervention above and beyond the provision of antiretroviral therapy.

Moreover, around 15% of adults and 26% of adolescents living with HIV cite feeling depressed or overwhelmed as a barrier to HIV treatment adherence. A meta-analysis of studies mostly conducted in the U.S. suggested that treating depression can improve adherence to antiretroviral therapy. When the interventions specifically targeted depression, rather than treating it as a secondary objective, results were better. Furthermore, the greatest impact was seen in patients with a low CD4 cell count or moderate to severe depression symptoms, or when treatments of a longer duration were used.

A recent prospective cohort study from Tanzania found that 58% of women beginning HIV treatment had symptoms consistent with depression, with around a third mentioning each of the following: loss of sexual interest, low energy, worrying too much, and blaming themselves; 1 in 6 women said they sometimes felt like ending their life.

Depression was associated with mortality in this study; 2 years after beginning HIV treatment, 6.6% of women with depression symptoms and 3.7% of other women had died. After adjustment for other factors, women with depression symptoms were twice as likely to have died.

One of the challenges of addressing mental health is the dearth of mental health workers in many settings. There is 1 mental health worker per 100,000 people in low-income countries, compared to 52 workers per 100,000 people in high-income countries.

Task shifting is therefore key. In a recently published randomized controlled trial, lay health workers in Zimbabwe were trained and supervised to provide individual problem-solving therapy. Those who received the intervention -- 42% of whom had HIV -- had fewer depression symptoms after 6 months. The evidence base for task shifting in mental health in resource-limited settings has grown considerably in recent years, Collins said.

To give another example, a small pilot study in Cameroon used depression care managers, a non-physician role that can be fulfilled by nurses or social workers after training. Working within HIV clinical services, they provided support to an HIV clinician, giving advice on depressive symptoms and the use of antidepressant medication, based on a treatment algorithm.

After 4 months, nearly all participants had a considerable improvement in their depressive illness. The intervention also appeared to have an impact on HIV outcomes, including CD4 cell count, viral load, symptoms, and medication adherence.

In Uganda, a group support psychotherapy intervention for people with HIV, using problem-solving and cognitive-behavioral approaches, reduced depression symptoms. Support groups exist in many settings, Collins said, but can be enhanced by adding evidence-based interventions for depression.

Integrating care for mental disorders and HIV is feasible, she said. This means making the screening and treatment of mental disorders a normative part of HIV care. Consensus needs to be achieved on who delivers services -- nurses, adherence counselors, community health workers, peers, or other groups. People seeking services, healthcare providers, managers, and policymakers need to be involved in decision-making about service integration, she said.


P Collins. Minimizing morbidity: integrating care for depression and HIV in low-resource settings. Conference on Retroviruses and Opportunistic Infections. Seattle, February 13-16, 2017. Abstract153.