- Category: Search for a Cure
- Published on Monday, 11 March 2013 00:00
- Written by Gregory Fowler
Starting antiretroviral therapy (ART) very early may restrict the size of the established HIV reservoir in long-lived T-cells, which could ultimately make it easier to achieve a functional cure, according to research presented last week at the 20th Conference on Retroviruses and Opportunistic Infections (CROI 2013) in Atlanta.
Jintanat Ananworanich from SEARCH and the Thai Red Cross AIDS Research Center in Bangkok and colleagues looked at the relationship between Fiebig stage -- a classification system for staging early HIV infection -- and levels of HIV DNA in peripheral blood cells and gut tissue. They found that people at the earliest stages of infection had extremely low reservoir size, and that starting treatment this early appears to restrict "seeding" of long-lived central memory T-cells.
[Jintanat Ananworanichspeaks with Matt Sharp about HIV reservoirs, CROI 2013, Atlanta, March 3, 2013]
J Ananworanich,C Vandergeeten, N Chomchey, et al. Early ART Intervention Restricts the Seeding of the HIV Reservoir in Long-lived Central Memory CD4 T Cells. 20th Conference on Retroviruses and Opportunistic Infections. Atlanta, March 3-6, 2013. Abstract 47.