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IAS 2015: Same-day Antiretroviral Treatment Leads to Faster HIV Suppression in San Francisco

A program at San Francisco General Hospital (SFGH) that offers antiretroviral therapy (ART) on the same day as HIV diagnosis led to a high rate of treatment uptake and more rapid viral load suppression than standard practices, according to late-breaking study findings presented at the 8th International AIDS Society Conference this week in Vancouver. Newly diagnosed people with HIV and clinic providers both expressed enthusiasm about the RAPID program, which is now being implemented more widely as part of the city's Getting to Zero initiative.

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IAS 2015: HIV Cure Research: The Next Year [VIDEO]

Sharon Lewin from the University of Melbourne offered a brief preview of what HIV functional cure and remission research might look like in the coming year, during an HIV cure press conference at the 8th International AIDS Society Conference on HIV Pathogenesis, Treatment, and Prevention this week in Vancouver.

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IAS 2015: Maturation Inhibitor BMS-955176 Shows Good Antiviral Activity with Atazanavir

The next-generation HIV maturation inhibitor BMS-955176 was well-tolerated and suppressed HIV viral load as well as standard antiretroviral therapy (ART) when used in a combination with atazanavir (Reyataz) in a 28-day study, according to late-breaking results from a small study presented at the 8th International AIDS Society Conference this week in Vancouver.

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Combination ART consists of agents that target different steps of the HIV lifecycle, but none of the currently approved drugs inhibit viral assembly, maturation, and release from host cells. If larger studies confirm its safety and efficacy, BMS-955176 could be the first drug in a new class of antiretrovirals that may offer an important treatment option for people with HIV who have developed extensive resistance to existing drug classes.

HIV uses an infected cell's machinery to produce complex polyproteins that are then cut up by protease enzymes and assembled into new virus particles. The final steps include forming a capsid around new viral genetic material and "budding" out through the cell's membrane, resulting in a mature infectious virion. Maturation inhibitors like BMS-955176 interfere with protease cleavage between the viral p24 capsid protein and a smaller peptide in the Gag polyprotein, leading to the release of immature virus that cannot infect other cells.

An older maturation inhibitor candidate, bevirimat (PA-457), initially showed promising antiviral activity, but it was hampered by formulation problems. Worse, more than half of study participants had reduced susceptibility to bevirimat due to naturally occurring HIV Gag variations.

In early studies the newer maturation inhibitor BMS-955176 showed activity against HIV that was not susceptible to bevirimat, as well as virus with resistance to nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs), NNRTIs, protease inhibitors, and integrase inhibitors.

BMS-955176 has a long half-life in the body, allowing for once-daily dosing, and no significant safety issues have been identified so far. In a proof-of-concept study presented at this year's Conference on Retroviruses and Opportunistic Infections, BMS-955176 reduced HIV RNA by about 1.6 log when used as monotherapy for 10 days.

Carey Hwang from the Bristol-Myers Squibb HIV Global Development Team and colleagues conducted a Phase 2a study to evaluate BMS-955176 used in conjunction with atazanavir for 28 days.

Due to the proximity of their sites of inhibition in the viral lifecycle, the drugs may have synergistic activity, the researchers noted as background. This combination could potentially offer a NRTI-sparing regimen for people who cannot tolerate or are resistant to NRTIs.

Study AI468002 (NCT01803074) enrolled 28 adults with HIV subtype B. Participants could be either treatment-naive or previously treated with drugs other than HIV protease inhibitors or maturation inhibitor candidates. All were men and most were white. At baseline the median CD4 T-cell count was approximately 500 cells/mm3 and the median viral load was about 4.2 log.

Study participants were randomly assigned to receive once-daily oral BMS-955176 at doses of either 40 mg or 80 mg plus either 300 mg atazanavir boosted with 100 mg ritonavir, or 400 mg unboosted atazanvir. A control group received standard therapy using tenofovir/emtricitabine (the drugs in Truvada) plus boosted atazanavir. Treatment continued for 28 days, with follow-up through day 42.

Results

  • Viral load rapidly declined in all treatment arms. Median declines in HIV RNA the day after the last dose ranged from -1.66 to -2.18 log in the 3 BMS-955176 arms, comparable to the -2.22 logdrop seen in the standard therapy arm.
  • Maximum median viral load declines were -2.02 logfor people taking 40 mg BMS-955176 with boosted atazanavir, -1.86 logfor those taking 40 mg BMS-955176 with unboosted atazanavir, and -2.23 logfor those taking 80 mg BMS-955176 with unboosted atazanavir, compared with -2.39 logusing standard therapy.
  • Short-term treatment with BMS-955176 was generally safe and well-tolerated, with no serious adverse events or study discontinuations due to adverse events. One person in the 80 mg arm developed transient neutropenia (low white blood cells).
  • A majority of people who used ritonavir-boosted atazanavir, either with 40 mg BMS-955176 or in the standard-of-care regimen, experienced grade 3-4 bilirubin elevations -- a known side-effect of atazanavir; however, this occurred in just 2 of the 16 people using unboosted atazanavir.
  • Bilirubin increased by a median of 60.0 mcmol/L in the 40 mg BMS-955176 plus boosted atazanavir arm and 41.8 in the standard therapy arm, compared with 11.8 and 7.7 mcmol/L, respectively, in the 40 mg and 80 mg BMS-955176 arms with unboosted atazanavir.

BMS-955176 80 mg plus atazanavir or BMS-955176 40 mg plus atazanavir and ritonavir "demonstrated similar antiviral activity compared to the standard of care control over the 28-day treatment period," the researchers concluded. "BMS-955176 plus unboosted atazanavir was associated with lower median changes from baseline in bilirubin levels compared to the arms with boosted atazanavir."

Bristol-Myers Squibb announced in a press release that a pair of Phase 2b studies of BMS-955176 have started this year: a traditional dose-finding study (NCT02415595) for treatment-naive people and a study evaluating a NRTI- and booster-sparing regimen for treatment-experienced patients.

7/21/15

Reference

C Hwang, D Schürmann, C Soboths, et al. Second-generation HIV-1 maturation inhibitor BMS- 955176: antiviral activity and safety with atazanavir +/- ritonavir. 8th International AIDS Society Conference on HIV Pathogenesis, Treatment, and Prevention. Vancouver, July 19-22, 2015. Abstract TUAB0106LB.

Bristol-Myers Squibb. Second-Generation Investigational HIV-1 Maturation Inhibitor Demonstrates Positive New Phase IIa Results, Supporting Continued Development. Press release. July 21, 2015.

IAS 2015: New NNRTI Doravirine Suppresses HIV as Well as Efavirenz But with Fewer CNS Side Effects

Merck's next-generation NNRTI doravirine (formerly known as MK-1439) was found to be as effective as efavirenz at suppressing HIV replication, but half as many study participants taking doravirine experienced drug-related adverse events -- in particular central nervous system (CNS) side effects -- and were less likely to stop treatment prematurely, according to study findings reported this week at the at the 8th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention this week in Vancouver.

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IAS 2015: START Trial Provides Definitive Evidence of Benefits of Early HIV Treatment

People who start antiretroviral therapy (ART) immediately after an HIV diagnosis -- while their CD4 T-cell count is still high -- rather than waiting until it falls below 350 cells/mm3 have a significantly lower risk of illness and death, according to long-awaited findings from the START trial presented at the 8th International AIDS Society Conference this week in Vancouver and published simultaneously in the July 20 advance edition of the New England Journal of Medicine.

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IAS 2015: Young Woman Stays Undetectable for 12 Years Off Treatment After Early HIV Therapy

The 8th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015) heard on Monday of a case of a young woman who was infected with HIV at birth and received very early antiretroviral therapy as a child, and has stayed off therapy since the age of 6 with a viral load well below the detectability limit of standard tests. Such "post-treatment controllers" are models for a "functional cure," which is one of the goals of HIV treatment research.

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IAS 2015: A New Era of HIV Treatment and Prevention [VIDEO]

Nearly 20 years after the last major AIDS conference in Vancouver ushered in the era of life-saving antiretroviral therapy, we are now embarking on a new era of HIV treatment and prevention. "Vancouver is going to make history again -- treatment as prevention will be definitively established as the new standard of care," said conference co-chair Julio Montaner, kicking off the 8th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention (IAS 2015).

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