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CROI 2014: Novel 2-Drug Maintenance Combo Works Well, Stage Set for Long-lasting Injectables

An oral combination of 2 antiretroviral drugs -- the non-nucleoside reverse transcriptase inhibitor rilpivirine (Edurant, also in Complera or Eviplera) and the new integrase inhibitor GSK1265744 -- was at least as effective as a standard NRTIs-plus-efavirenz triple combination in keeping viral load undetectable, according to a report presented at the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) last week in Boston.

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CROI 2014: Long-Acting HIV Drugs for Maintenance Therapy [VIDEO]

A combination of 2 antiretrovirals used as maintenance therapy for people with undetectable viral load -- the next-generation integrase inhibitor GSK1265744 and the NNRTI rilpivirine (Edurant) -- led to continued viral suppression in more than 80% of treated patients, according to a report at the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) last week in Boston.

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This study was done in preparation for a trial of long-acting injectable formulations of GSK1265744 (or GSK744 for short) and rilpivirine. These findings suggest that these drugs may be feasible for long-term maintenance therapy, though concerns remain about development of resistance under certain circumstances.

[David Margolis, CROI press conference, March 5, 2014]

See also: CROI 2014: Novel 2-Drug Maintenance Combo Works Well, Stage Set for Long-lasting Injectable [study report]

3/10/14

Reference

D Margolis, C Brinson, J Eron, et al. 744 and Rilpivirine as Two-Drug Oral Maintenance Therapy: LAI116482 (LATTE) Week 48 Results. 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014). Boston, March 3-6. Abstract 91LB.

Coverage of the 2014 Conference on Retroviruses and Opportunistic Infections

HIVandHepatitis.com coverage of the 21st Conference on Retroviruses and Opportunistic infections (CROI 2014), March 3-6, 2014, in Boston.

Conference highlights include new treatments for hepatitis C, HIV experimental therapies and treatment strategies, HIV cure research, HIV-related conditions, treatment as prevention and PrEP, and HIV/HCV coinfection.

Full HIVandHepatitis.com coverage by topic

Selected presentations and slide webcasts 

3/9/14

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CROI 2014: Raltegravir Works as Well as Tenofovir for HIV Treatment [VIDEO]

A NRTI-sparing first-line antiretroviral regimen of raltegravir (Isentress) plus ritonavir-boosted darunavir (Prezista) worked as well as standard therapy containing tenofovir/emtricitabine (the drugs in Truvada), according to results from the NEAT 001 trial presented at the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) last week in Boston.

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[Francois Raffi, CROI press conference, March 5, 2014]

See also: CROI 2014: Raltegravir Plus Boosted Darunavir Is Safe and Effective for First-line ART [study report]

3/10/14

Reference

F Raffi, AG Babiker, L Richert, et al. First-Line RAL + DRV/r Is Non-Inferior To TDF/FTC + DRV/r: The NEAT001/ANRS143 Randomised Trial. 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014). Boston, March 3-6. Abstract 84LB.

CROI 2014: Boston Patients Experience HIV Rebound after Stem Cell Transplants

HIV has re-emerged in 2 Boston men who underwent experimental antiretroviral therapy (ART) interruption after receiving bone marrow stem cell transplants for cancer treatment, Timothy Henrich reported at the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) this week in Boston. These cases suggest that a functional cure for HIV will be difficult to achieve if even a small amount of residual virus remains in the body.

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Coverage of the 2014 Conference on Retroviruses and Opportunistic Infections

HIVandHepatitis.com coverage of the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014), March 3-6, 2014, in Boston.

Conference highlights include new treatments for hepatitis C, HIV experimental therapies and treatment strategies, HIV cure research, HIV-related conditions, treatment as prevention and PrEP, and HIV/HCV coinfection.

Full listing by topic

Selected presentations and slide webcasts 

3/9/14

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CROI 2014: HIV Rebounds in Boston Bone Marrow Transplant Patients [VIDEO]

Detectable HIV has returned in 2 Boston stem cell transplant recipients who for a time appeared to be controlling the virus during antiretroviral treatment interruption, Timothy Henrich from Brigham and Women's Hospital reported at the reported at the 21st Conference on Retroviruses and Opportunistic Infections (CROI 2014) this week in Boston.

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