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CROI 2016: Combination Inhibitor BMS-986197 Demonstrates Good Anti-HIV Activity in Early Study

A long-acting bioengineered "combinectin" molecule with a triple mechanism of action demonstrated potent antiviral activity and worked against HIV that developed resistance to any of the 3 separate mechanisms in a laboratory study, and lowered viral load in humanized mice, according to research presented at the Conference on Retroviruses and Opportunistic Infections (CROI 2016)last month in Boston.

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CROI 2016: Removing Clinic Barriers to Rapid ART in Uganda Enables 70% to Start on Same Day

Making point-of-care CD4 T-cell count diagnostics available, revising adherence counseling requirements, and giving extra training to healthcare workers can almost quadruple the number of patients who begin antiretroviral therapy (ART) on the day that they are eligible, Gideon Amanyire of Makerere University reported at the at the Conference on Retroviruses and Opportunistic Infections (CROI 2016)last month in Boston. The package of health system reforms was provided to a typical "real world" group of clinics in Uganda and was embedded in everyday practice, suggesting that the same intervention could have a similar impact elsewhere.

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FDA Approves Second TAF-Containing Single-Tablet HIV Regimen

The U.S. Food and Drug Administration (FDA) this week approved Gilead Sciences' new once-daily single-tablet regimen Odefsey, containing the NNRTI rilpivirine (developed by Janssen), emtricitabine, and tenofovir alafenamide or TAF, a new formulation that is easier on the kidneys and bones than the older tenofovir disoproxil fumarate or TDF.

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Updated U.S. Guidelines for Antiretroviral Treatment of Children with HIV

The U.S. Department of Health and Human Services has updated its Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection. Reflecting recent data from the START and PENPACT1 trials, the guidelines now recommend that all children with HIV start antiretroviral therapy (ART) regardless of CD4 T-cell count, viral load, or clinical symptoms.

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CROI 2016: Expanding Treatment and PrEP Could Prevent 185,000 New HIV Infections, CDC Says

Increasing diagnosis, care, and treatment of people living with HIV could lead to a large decrease in HIV incidence, preventing some 168,000 new infections by the year 2020, according to a new Centers for Disease Control and Prevention (CDC) analysis presented at the Conference on Retroviruses and Opportunistic Infections (CROI 2016)last week in Boston. The impact of pre-exposure prophylaxis (PrEP) would be comparatively modest, but its importance would be greater if more HIV-positive people are not on treatment with undetectable viral load.

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CROI 2016: START Study Shows People Starting HIV Treatment Earlier Have Better Quality of Life

Rather than treatment side effects having a negative impact on people’s quality of life when they start HIV treatment, data from the large randomized START study show a modest but statistically significant improvement in quality of life, according to a presentation at the recent Conference on Retroviruses and Opportunistic Infections (CROI 2016) in Boston.

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CROI 2016: Experimental TLR7 Agonist Suppresses HIV-Like Virus in Monkeys After ART Interruption

GS-9620, an investigational toll-like receptor or TLR7 agonist, led to immune activation in a study of macaque monkeys infected with an HIV-like virus, and 2 of the animals treated with multiple doses have maintained viral suppression for at least 3 months after stopping antiretroviral treatment, according to research presented at the Conference on Retroviruses and Opportunistic Infections (CROI 2016) last week in Boston.

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