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CROI 2013: Case Report of a 'Functional' HIV Cure in a Child

Researchers in the U.S. say that they have identified a case of a "functional" HIV cure in a child infected with HIV who began antiretroviral treatment within days of birth. The child has now been off treatment for over a year, and although HIV DNA has been detected at very low levels in the child’s cells, the virus is not reproducing.

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Tenofovir, Protease Inhibitors Linked to Kidney Impairment

Use of tenofovir disoproxil fumarate (TDF) is associated with reduced kidney function, though for most people the change is small, does not progress with continued exposure, and improves after stopping the drug, according to several recently published studies. Some analyses found that certain HIV protease inhibitors can also cause kidney problems.

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Updated HIV Treatment Guidelines Include Stronger Recommendation for Acute Infection

On February 12, 2013, the U.S. Department of Health and Human Services antiretroviral therapy (ART) guidelines panel issued an update to the adult and adolescent HIV treatment guidelines. Among the key changes are additional information about the most recently approved antiretroviral agents and a recommendation that newly infected people with HIV should be offered combination ART.

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CROI 2013: Retrovirus Conference Starts Sunday in Atlanta

The 20th Conference on Retroviruses and Opportunistic Infections (CROI 2013) kicks off Sunday, March 3, at the Georgia World Congress Center in Atlanta. HIVandHepatitis.com will be on site next week to bring you breaking news coverage on HIV and hepatitis C.

Look for reports from the HIVandHepatitis.com team and our content partners at NAM/Aidsmap.com starting Monday. Sign up for our email newsletter to get the latest headlines and follow us on Twitter @HIVandHepatitis.alt

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Even Small Viral Load Reduction Is Beneficial for People with Highly Resistant HIV

Antiretroviral therapy (ART) can help raise CD4 T-cell counts even if it does not produce undetectable HIV RNA due to extensive drug resistance, indicating that treatment likely has immunological benefits even for people with few therapeutic options, according to a report in the March 1, 2013 Journal of Infectious Diseases.

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Dolutegravir Active against Raltegravir-resistant HIV, Granted FDA Priority Review

ViiV Healthcare announced last week that the U.S. Food and Drug Administration has given a priority review designation for its investigational HIV integrase inhibitor dolutegravir, which has demonstrated good efficacy in both treatment-naive and treatment-experienced people.

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Atazanavir (Reyataz) Label Update Adds Kidney Warning, Drug Interactions

Product label information for the HIV protease inhibitor atazanavir (brand name Reyataz) was recently revised to include new warnings about cholelithiasis or gall bladder stones and interstitial nephritis (a type of kidney inflammation), as well as interactions with several other medications, including the hepatitis C virus protease inhibitor boceprevir (Victrelis).

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