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USCA 2016: U.S. Conference on AIDS Discusses HIV Prevention and Access to Care

The U.S. Conference on AIDS (USCA 201c), sponsored by the National Minority AIDS Council,is taking place this week, September 15-18, in Hollywood, Florida. The largest U.S. conference focused on the community-based response to HIV/AIDS, USCA brings together researchers, front-line providers, community organizations, government policymakers, and people living with HIV and their advocates to discuss how to improve access to HIV prevention, care, and treatment.


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AIDS 2016: Realism Needed About the Benefits and Risks of Taking Part in HIV Cure Research

A significant proportion of people living with HIV would be willing to take part in a study towards a cure for HIV, according to research presented at the recent 21st International AIDS Conference (AIDS 2016) in Durban. However, some potential participants may not fully understand that taking part in an early-phase study is highly unlikely to afford any personal clinical benefit, but might have the potential to cause harm.


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AIDS 2016: Efavirenz Appears Associated with Elevated Suicide Risk in START Trial

Participants in the START treatment-timing trial who took antiretroviral regimens containing efavirenz had an increased risk of suicidal and self-injuring behavior than those not using efavirenz, though the number of events was small and the effect was mainly seen among people with a prior psychiatric diagnosis, according to research presented at the 21st International AIDS Conference last month in Durban.


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AIDS 2016: HIV Will Only Be Cured with Combined Approaches, Conference Delegates Hear

Curing people of HIV infection will have to involve combinations of drugs and approaches, just as HIV treatment does, delegates heard at the Towards an HIV Cure workshop held in advance of the recent 21st International AIDS Conference (AIDS 2016) in Durban. The reason is the same, too: HIV can easily develop resistance to single agents, even ones as sophisticated as broadly neutralizing antibodies and gene-editing enzymes.


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AIDS 2016: International AIDS Society Releases New HIV Cure Research Strategy

The International AIDS Society (IAS) released an update to its strategy to guide HIV cure research. The strategy, authored by the leading researchers in the field, was published in the July 11 online edition of Nature Medicine and discussed at the IAS Towards an HIV Cure Symposium preceding the 21st International AIDS Conference last month in Durban.alt

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AIDS 2016: Mapping Local HIV Epidemics Can Help Target Resources to Areas with Greatest Need

Global health agencies have recently put a new emphasis on geography. UNAIDS has called for programs to focus on "location and population." PEPFAR (the U.S. President's Emergency Plan for AIDS Relief) says there is a "need to do the right things in the right places at the right time." The Global Fund believes there is a need to "target resources to areas with the greatest need." But how can these principles be applied in practice? Speakers at the 21st International AIDS Conference (AIDS 2016) last month in Durban outlined examples of how maps and geographical analyses have helped improve HIV services in the U.S. and South Africa.



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Mapping HIV in the U.S.

Travis Sanchez from Emory University in Atlanta introduced AIDSVu, a set of interactive, online maps that allows users to visually explore the HIV epidemic in the U.S. By making it readily accessible to policy-makers, it has been used to better target limited healthcare and HIV prevention resources.

For example, Sanchez showed maps of Chicago, showing rates of diagnosed HIV in different parts of the city, broken down by ethnic group. As expected, rates among black people are higher than among whites, and this is the case throughout the city. But the map highlighted some unexpected clusters of cases -- high rates among white people in some predominantly black zip codes in the city’s south-central area, as well as high rates among black people in some predominantly white zip codes in the northeast of the city.

In Philadelphia, health officials used HIV prevalence data at the census-tract level (the most detailed unit available, covering a neighborhood with a few thousand residents) in order to target door-to-door testing campaigns. "This is really about targeting local resources in the local communities that need them most," Sanchez said.

While mapping rural Alabama, it became clear that a number of counties with high rates of HIV were also designated as "Health Professional Shortage Areas." With HIV concentrated in deprived populations that have limited access to transportation to medical facilities further afield, there is a potential for people to drop out of care and have uncontrolled viral load. In response, health officials set up a telemedicine service so that primary care clinics in the underserved areas could be linked with medical providers elsewhere in Alabama. A web-based video link (a bit like a Skype call) allows patients to receive medical care and counseling at a distance. 

In Atlanta, the mapping demonstrated how HIV and poverty overlapped. Looking into the data in more detail, "hot spots" of poor linkage to care and low rates of viral suppression were identified. While some areas of high HIV prevalence were served by HIV treatment facilities, several other hot spots were far from medical facilities, with low rates of car ownership and poor public transportation links.

Sanchez said that mapping these relationships had been "transformational" in helping local officials identify the structural barriers to care and prepare the local Strategy to End AIDS. The plans place emphasis on creating patient-friendly systems that facilitate entry into care, including transportation support.

Mapping in South Africa

Frank Tanser from the Africa Centre for Population Heath has been intensively studying a rural, poor area of KwaZulu-Natal in South Africa. His mapping shows that HIV incidence, HIV prevalence, and deaths are far from evenly distributed, with all 3 highly concentrated in informal settlements and peri-urban areas bordering a major highway.

"I think these maps speak to the tyranny of averages," Tanser said. Rather than spreading healthcare resources evenly across all areas, there’s an opportunity to use this "incredible spatial heterogeneity" to focus investment on the most vulnerable populations and so bring epidemics under control, he said.

The maps have identified "hot spots" in which a significant proportion of people have uncontrolled HIV -- in some specific locations, more than 1 in 4 adults in the general population have a detectable viral load. Such communities may not only have a high burden of HIV themselves, but may also be driving onward transmission in the wider geographical area.

Phylogenetic analysis (examining the genetic links between HIV in different individuals) suggests that a high proportion of new infections in other communities can be linked back to individuals living in the "hot spot" communities beside the highway. Transportation and migration are likely to play an important part in this.

Targeting resources so as to improve the treatment cascade in these specific locations could have a disproportionate impact on the larger epidemic, Tanser suggested.

Overcoming Data Limitations

The examples presented at the conference depend on rich sources of data. AIDSVu links extensive data collected by American public health agencies with socioeconomic information from the U.S. census. The Africa Centre conducts intensive HIV surveillance activities within a 20 by 20 km area. How then can the approach be applied in settings where such resources are not available?

Tanser said that insights derived from studies, such as the relationship between distance to health facilities and HIV prevalence, would likely be applicable elsewhere. Other urban and peri-urban informal settlements in African countries are likely to be "hot spots." Those located near major transport routes are especially likely to contribute to new infections, but can also be easily reached by health providers.

One important gap in routinely collected data is that it rarely records details that would identify individuals as members of key populations, such as sex workers or people who inject drugs. As a result, key populations tend to be invisible in many spatial analyses although they may cluster in specific areas. Tanser said that there was potential to apply geographical analyses to key populations (using respondent-driven sampling) but that there could be sensitivities when mapping stigmatized and criminalized groups.

Closing the session, Gesine Meyer-Rath said that funders were often very interested in mapping, as targeting could mean that financial resources could be used more efficiently. This could be a way of justifying spending less. But she said that the same data could also be used by activists and members of affected communities to demand services where they really are needed.



Using Geospatial Analysis for Effective HIV Programming. 21st International AIDS Conference. Durban, July 18-22, 2016. Session THSY05.

T Sanchez. The direct programme impacts of publicly available tools to visualize spatial patterns in HIV infection in the United States: the AIDSVu experience. 21st International AIDS Conference. Durban, July 18-22, 2016. Presentation THSY0503.

F Tanser. Application of geospatial analyses to reveal targets for intervention: results from a population-based cohort in rural KwaZulu-Natal, South Africa. 21st International AIDS Conference. Durban, July 18-22, 2016. Presentation THSY0504.

AIDS 2016: Seeking a Cure, Doctors Document Bone Marrow Transplant Recipients with HIV

The "Berlin patient," Timothy Ray Brown, has now survived 7 years off antiretroviral therapy (ART) with no sign of HIV reappearing in his body, and as time passes his position as "the person cured of HIV" becomes more secure. However, participants at the 2016 Towards a Cure Symposium, held in advance of the recent 21st International AIDS Conference (AIDS 2016) in Durban, heard about the work of a consortium of physicians and researchers who are searching for, and documenting, the fates of patients with HIV who, like Brown, have been given stem cell transplants for cancer, in an effort to abolish Brown’s distinction as the only person to be cured of HIV.


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