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October 29 Is World Stroke Day

Saturday, October 29, has been designated World Stroke Day, an opportunity to raise awareness about how to prevent strokes -- which studies indicate occur more often among people with HIV and those with hepatitis C -- and how to recognize stroke symptoms to enable prompt treatment.

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EACS: Incidence of Non-AIDS Malignancies Stabilizes in D:A:D Study, but Prognosis Improves

Occurrence of non-AIDS-defining cancer has remained stable in recent years, according to an analysis of the large D:A:D observational cohort presented at the 13th European AIDS Conference (EACS 2011) last week in Belgrade. Prognosis for HIV positive people with such malignancies remains poor, but appears to have improved somewhat over time.alt

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HIV+ People on ART Have Stable Bone Density after Short-term Loss

People with HIV tend to experience a loss of bone mineral density soon after starting antiretroviral therapy (ART), but the decline reaches a plateau after about 1 year and remains quite stable thereafter, according to a meta-analysis of nearly 40 studies described in the September 2011 Journal of Clinical Endocrinology and Metabolism.

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EACS: Neurocognitive Impairment in People with HIV

How much more common is brain impairment and dementia in people with HIV than in the general population? A study presented at the 13th European AIDS Conference (EACS 2011) this week in Belgrade showed that the answer could vary from "no more common" to "4 times as common," according to which group you studied, which sample of the HIV negative population you compared them with, and whether you averaged their neurocognitive (NC) performance over all domains or picked out specific areas of impairment.

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FDA Considers Limits on Osteoporosis Drugs Due to Fracture Risk

An advisory committee of the U.S. Food and Drug Administration (FDA) last week weighed the risks and benefits of bisphosphonate drugs such as alendronate (Fosamax) for managing osteoporosis. The committee recommended limiting the duration of bisphosphonate use, but did not agree on a time frame.alt

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Elevated Triglycerides and Waist Circumference Predict Cardiovascular Risk for People with HIV

HIV positive people with high triglyceride levels and large girth were more likely to have other risk factors associated with cardiovascular disease and events such heart attacks, suggesting that these 2 simple measures may be used to distinguish high-risk versus low-risk individuals, according to a study in the September 22, 2011, edition of the open access journal PLoS ONE.

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Cryptococcus May Be Misdiagnosed in People with AIDS

People with AIDS who contract cryptococcal infection may have a different organism than usually suspected, Cryptococcus gattii rather than Cryptococcus neoformans, according to a study in the September 1, 2011, online edition of PLoS Pathogens. Prevalence of C. gattii varies by region, and correct identification can help select the most effective treatment.alt

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Function Imaging Changes May Reflect Brain Impairment during Early HIV Infection

Functional magnetic resonance imaging during the early stages of HIV disease reveals changes in connectivity in the brain that may be due to high-level viral replication soon after infection, according to a study in the September 20, 2011, issue of Brain Connectivity. Researchers suggested this method may be useful as a non-invasive marker for future neurocognitive impairment.

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Diet, Exercise, and Niacin/Fenofibrate Improves Blood Lipids in People with HIV

A combination approach including low-fat diet, exercise, and niacin plus fenofibrate increased HDL good cholesterol and reduced bad cholesterol and triglycerides in HIV positive people on antiretroviral therapy (ART) with abnormal blood lipid levels, researchers reported in the July 2011 Journal of Clinical Endocrinology and Metabolism.

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