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Starting ART below 350 CD4 Cells is Associated with Impaired Artery Function

HIV positive people who ever had a CD4 T-cell count below 350 cells/mm3 are more likely to have reduced flow-mediated dilation, a sign of blood vessel dysfunction linked to cardiovascular events such as heart attacks, according to a study described in the June 1, 2012, issue of AIDS. These findings suggest that starting antiretroviral treatment above this CD4 level may be beneficial.

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Cryptococcal Meningitis Study Halted after Early HIV Treatment Linked to Higher Mortality

A study looking at timing of antiretroviral therapy (ART) in people with cryptococcal meningitis was stopped early because patients who started HIV treatment immediately had a higher risk of death than those who waited until a few weeks after starting meningitis treatment.

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HIV Infection Associated with Increased Risk of Lung Cancer and Other non-AIDS Malignancies

HIV positive people have about a 70% higher rate of lung cancer compared with a similar HIV negative population, according to a U.S. veterans study described in the May 15, 2012, issue of AIDS. Related studies of cancer risk presented at the 19th Conference on Retroviruses and Opportunistic Infections (CROI 2012) in March also saw higher rates of non-AIDS malignancies among people with HIV.alt

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ASCO 2012: Breast Cancer Outcomes among HIV Positive Women

Women with HIV can do well on a variety of different types of treatment for breast cancer, but they are prone to infections and blood cell deficiencies and may benefit from adjunct therapies, researchers reported at the American Society of Clinical Oncology Annual Meeting (ASCO 2012) taking place this week in Chicago.

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Zoledronate Protects HIV Positive Men against Bone Loss for at Least 5 Years

The effects of 2 annual doses of zoledronate persist for at least 5 years in HIV positive men on antiretroviral therapy (ART), according to a New Zealand study published in the March 14, 2012, advance online edition of the Journal of Clinical Endocrinology & Metabolism.alt

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HIV Infection Linked to Increased Stroke Risk

HIV positive people may have a higher risk of stroke independent of traditional risk factors, with the largest relative increase among younger people and women, according to study findings published in the May 10, 2012, advance online edition of the Journal of Acquired Immune Deficiency Syndromes.alt

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CROI 2012: Switching to Tenofovir Increases Bone Turnover, Raltegravir Can Improve Bone Density

HIV positive people who substituted tenofovir (Viread) for zidovudine (AZT; Retrovir) in their antiretroviral regimen showed elevated levels of biomarkers associated with bone turnover and decreased bone mineral density (BMD), researchers reported at the 19th Conference on Retroviruses and Opportunistic Infections (CROI 2012) last month in Seattle. A related study found that switching from tenofovir to raltegravir (Isentress) led to increases in bone density.alt

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Bisphosphonate Drugs Linked to Atypical Femur Fractures, but Absolute Risk is Small

Use of bisphosphonates, a class of drugs used to manage bone loss and prevent fractures, actually appears to increase the likelihood of an unusual type of femur (thigh bone) fracture, according to a retrospective analysis described in the advance online edition of Archives of Internal Medicine. Researchers emphasized, however, that the absolute risk of atypical femur breaks remains very low. alt

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CROI 2012: Elevated Blood Pressure Linked to Heart Attack Risk in HIV+ People

HIV positive people with elevated blood pressure are at higher risk for myocardial infarction, or heart attack, even if they do not meet the definition for high blood pressure, researchers reported at the 19th Conference on Retroviruses and Opportunistic Infections (CROI 2012) this month in Seattle.alt

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